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NFL Best Bet of the Day – Jaguars vs. Bills (2024)

NFL Best Bet of the Day – Jaguars vs. Bills (2024)

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Week 3 in the NFL concludes with a Monday night doubleheader with the earlier matchup featuring the winless Jacksonville Jaguars (0-2) taking on the undefeated Buffalo Bills (2-0) at Highmark Stadium in Orchard Park, New York. Today, we’re taking a look at our NFL best bet of the day, featuring the Jaguars and the Bills.

Let’s take a deep dive and examine my favorite best bet between the Jaguars and Bills.

All NFL odds and lines are current as of Sunday, September 22, at 8:00 PM, EST and courtesy of DraftKings Sportsbook.

Domenic Lunardo’s 2024 NFL Betting Record: 3-0-0 (+2.32 units)

Best Bet: Bills Team Total – Over 24.5 Points

Sportsbook: DraftKings.

Odds: (-122)

Wager: 1 Unit

NFL Best Bet of the Day – Jaguars vs. Bills

Our NFL best bet of the day between Jacksonville and Buffalo will target the Over on the Bills’ team total in points, alternatively set at 24.5, on a single-unit wager.

The total for this one currently sits at 45.5 signifying professional oddsmakers and sportsbooks are anticipating a relatively high-scoring and eventful matchup between two AFC teams.

Furthermore, the Bills offense has looked confident and efficient in the early onset of the 2024 campaign, led in large part by the brilliance of quarterback Josh Allen.

As a team, Buffalo has also impressed in the advanced metrics/analytics sector of the game ranking first in football in both Percentage of On-Target Throws per Pass Attempt (88.1%) and Pocket Time (2.6 seconds), and sixth in Passing Yards After Catch per Completion (6.8).

On the other sideline, the Jaguars defense has struggled thus far this season ranking 23rd in the NFL in Opponents’ Yards per Game (348.5), 20th in Opponents’ Third-Down Conversions per Game (5.0), and 25th in Opponents’ Yards per Completion (10.9), per NFL Team Rankings.

It’s also important to note that the Bills enter tomorrow’s contest as heavy (-245) moneyline home favorites which carries with it a whopping 71.01% implied-win probability. This means that Buffalo is expected to play with the lead, dictate play, and ultimately put points on the board.

Look for the Bills to surpass 24.5 points in front of their home fans at a decent (-122) price point.


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Domenic Lunardo Domenic is a freelance sportswriter at Faceoff Sports Network and The Game Day. Previously, he wrote for The Hockey Writers, LWOS, and Prime Time Sports Talk. Over the past few years, Domenic has provided analysis more frequently in the sports betting industry and maintains an active presence on Twitter, primarily posting daily betting cards across the NHL, NFL, MLB, NBA, college basketball, and soccer. Although Domenic has a diverse sporting background, he specializes in hockey, football, and baseball.

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